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TOOLS Mag-Beads-Carboxyl is magnetic bead with surface functional group -COOH. The magnetic bead consists of a single-crystal Fe3O4 sphere core and dextran coating layer. Through chemical modification of dextran, the carboxyl groups (-COOH) are joined to the magnetic beads through a short hydrophilic linker. The hydrophilic surface ensures the magnetic beads excellent dispersion ability and easy handling property in a wide variety of buffers. Through activation of Mag-Beads-Carboxyl with EDC, the ligands could be conjugated to the magnetic beads through primary amine groups such as antibody, protein, or peptide.